“Creatine improves memory in healthy adults.”
Creatine does not reliably improve memory in healthy adults; trials in younger adults found no effect, and a possible small benefit appeared only in older adults.
If you are young and healthy, creatine is unlikely to sharpen your memory. Any benefit is small and has shown up mainly in older adults.
You do not need to start creatine for memory. If you already use it for training, you can keep going, but do not expect a memory boost from it.
Talk to a healthcare professional if: you notice new or worsening memory problems, or you have kidney disease and are thinking about taking creatine.
In healthy younger adults, trials show little or no memory effect. Any signal is mainly in older adults and rests on small studies with statistical problems.
A commonly cited review pooled healthy people with patients, and critics say it counted several memory tests from the same people as separate results, which can exaggerate the effect. A review limited to healthy people found a memory benefit mainly in adults aged 66 to 76 and none in people aged 11 to 31; a published letter showed the same double-counting problem, and a later commentary reports that a re-analysis kept a significant effect only in older adults. European regulators concluded in 2024 that a cognitive benefit has not been established.
The European regulators found that a short-term boost in working memory showed up in two studies that used 20 g a day for 5 to 7 days. It was not seen at lower doses of 2.2 to 14 g a day, or with 5 g a day for 6 weeks after a loading phase.
- Prokopidis K, Giannos P, Triantafyllidis KK, Kechagias KS, Forbes SC, Candow DG. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews. 2023;81(4):416-427. DOI: 10.1093/nutrit/nuac064. PMID: 35984306
- Xu C, Bi S, Zhang W, Luo L. The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Frontiers in Nutrition. 2024;11:1424972. DOI: 10.3389/fnut.2024.1424972. PMID: 39070254
- Citherlet T. Commentary: The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Frontiers in Nutrition. 2026;13:1716285. DOI: 10.3389/fnut.2026.1716285. PMID: 42039906
- EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D, Bohn T, Cámara M, et al. Creatine and improvement in cognitive function: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal. 2024;22(11):e9100. DOI: 10.2903/j.efsa.2024.9100. PMID: 39564533
- Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition. 2017;14:18. DOI: 10.1186/s12970-017-0173-z. PMID: 28615996