“Most adults should have Lp(a) checked at least once.”
Moderate confidence because Lp(a) helps identify inherited risk, and current guidance supports a one-time adult test. The testing recommendation is less direct evidence than a trial showing that screening itself prevents heart attacks.
A one-time adult Lp(a) measurement can identify inherited cardiovascular risk not captured by a standard lipid panel. Current American and European guidance therefore supports measuring it at least once in adulthood.
A one-time Lp(a) measurement can uncover inherited risk that a standard lipid panel misses, although testing recommendations and access can vary.
Ask about a one-time Lp(a) test at a routine cholesterol discussion, especially if premature heart disease runs in your family.
Similar claims on Lp(a): the risk factor standard panels miss
This is the single most under-tested item on this list, and it costs one blood draw you may only ever need once. If there is unexplained heart disease in your family, this is the question to ask.