“Carrageenan nasal sprays prevent colds.”
Carrageenan nasal sprays have not been shown to prevent colds: the only trial testing this found no clear drop in cold symptoms.
A carrageenan nasal spray is not a proven way to keep from catching colds. Trials found few side effects, but the one real test of prevention did not show a clear benefit.
You can skip carrageenan nasal sprays as a way to prevent colds.
The only trial that tested carrageenan spray for preventing colds found no clear benefit, and the other trials treated colds people already had. Confidence is Limited because that one prevention trial was small, and many people in it did not use the spray as directed.
Carrageenan nasal sprays have not been shown to prevent colds: the only trial testing this found no clear drop in cold symptoms. Most carrageenan studies treated colds people already had, which is a different question.
Carrageenan is a gum made from red seaweed. In lab studies it binds to cold viruses and blocks them from entering cells, which is the reason it is sold as a "barrier" spray, but lab results do not show what happens in people. In a New Zealand trial, 102 adults used a carrageenan spray or a salt-water spray three times a day for eight weeks; cold symptoms were slightly lower with carrageenan, but the difference could have been chance, and many people did not keep up with the spray. Four treatment trials with 599 people, in adults and children who already had colds, gave mixed results on symptoms. A small pilot trial of 394 hospital workers in Argentina found fewer COVID-19 cases with a carrageenan spray (1.0 percent versus 5.0 percent), but that is a different virus, in people with heavy exposure, and it did not test colds.
- Halley C, Honeywill C, Kang J, Pierse N, Robertson O, Rawlinson W, Stelzer-Braid S, Willink R, Crane J. Preventing upper respiratory tract infections with prophylactic nasal carrageenan: a feasibility study. Future Microbiology. 2023;18:1319-1328. DOI: 10.2217/fmb-2021-0122. PMID: 37830932
- Bichiri D, Rente AR, Jesus A. Safety and efficacy of iota-carrageenan nasal spray in treatment and prevention of the common cold. Medicine and Pharmacy Reports. 2021;94(1):28-34. DOI: 10.15386/mpr-1817. PMID: 33629045. PMCID: PMC7880062
- Eccles R, Winther B, Johnston SL, Robinson P, Trampisch M, Koelsch S. Efficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial. Respiratory Research. 2015;16:121. DOI: 10.1186/s12931-015-0281-8. PMID: 26438038. PMCID: PMC4595062
- Figueroa JM, Lombardo ME, Dogliotti A, Flynn LP, Giugliano R, Simonelli G, et al. Efficacy of a nasal spray containing iota-carrageenan in the postexposure prophylaxis of COVID-19 in hospital personnel dedicated to patients care with COVID-19 disease. International Journal of General Medicine. 2021;14:6277-6286. DOI: 10.2147/IJGM.S328486. PMID: 34629893. PMCID: PMC8493111