“NAD+ IV drips slow aging.”
NAD+ IV drips have not been shown to slow aging in people.
NAD+ drips raise a blood marker for a few hours, but nothing shows they slow aging or improve health. Paying for them adds needle and product risks without a proven payoff.
If you are thinking about NAD+ drips to slow aging, you can skip them.
Safety note: The FDA has warned that some compounded IV NAD+ was made from food-grade NAD+, which carries a high risk of germs and bacterial toxins, and it has received reports of severe chills, shaking, vomiting and tiredness after NAD+ injections, some needing medical care. Any IV drip also carries procedure risks: severe infections, including deaths, have been reported from poorly sterilized equipment, and drips can overload the body with fluid in people with heart conditions or high blood pressure.
Talk to a healthcare professional if: you have a heart condition, high blood pressure or kidney disease, or you are pregnant or breastfeeding, and are thinking about an IV drip; or you had chills, shaking, vomiting or trouble breathing during or after an infusion.
A 2026 review of 33 human studies found no trial that tested IV NAD+ for aging or wellness outcomes, and pills that raise NAD+ have shown no consistent health benefit. Confidence is limited because the only IV NAD+ study in people was a tiny blood-level test.
NAD+ IV drips have not been shown to slow aging in people. No trial has tested them for aging or health outcomes; the only human IV NAD+ study just tracked blood levels in 8 men for one day.
NAD+ is a molecule every cell uses to make energy, and its levels fall with age. In mice and rats, raising NAD+ often improved metabolism and other measures, but that is animal evidence. In people, a 2026 systematic review found 33 studies, mostly of NMN and NR pills that the body turns into NAD+. These pills reliably raised NAD+ in the blood, but effects on fitness, metabolism, blood vessels and other health measures were mixed and often absent. The review found no outcome trials of IV or injected NAD+ for anti-aging or wellness. The one IV NAD+ study in people gave 750 mg over 6 hours to 8 healthy men; blood NAD+ did not rise for the first 2 hours, then rose to about 400 percent above its starting level by hour 6, and no side effects were seen. That study was paid for in part by NAD+ Research Inc., and one author was a director of that company and medical director of a clinic that gives IV NAD+.
- Gallagher C, Emmanuel OO. NAD+ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence. Ageing Research Reviews. 2026;116:103057. DOI: 10.1016/j.arr.2026.103057. PMID: 41655607
- Grant R, Berg J, Mestayer R, Braidy N, Bennett J, Broom S, Watson J. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Frontiers in Aging Neuroscience. 2019;11:257. DOI: 10.3389/fnagi.2019.00257. PMID: 31572171. PMCID: PMC6751327
- US Food and Drug Administration. FDA reminds compounders to use ingredients suitable for sterile compounding. Human Drug Compounding. Content current as of 10/30/2024
- Shane-McWhorter L. Intravenous Vitamin Therapy (Myers' Cocktail). Merck Manual Consumer Version. Last updated July 2025